Who are you, and what do you do?
I write code, answer email, listen to metal, and help make GitHub more awesome. Or try to, at least.
What hardware do you use?
I also have a Logitech MX518 mouse and it's amazing. I've used the same one for five years and it still feels futuristic. It fits my hand perfectly, has buttons exactly where I want them (mapped to whatever I want with USB Overdrive), and the precision is outrageous. Every other mouse feels like I'm trying to pull the OS's cursor dingus through a pool of mud.
Kim Cuartero gave it to me back when we both worked at GameSpot. I use it atop a Ratpadz mouse pad I got for free while working at GameStop. So basically I got really lucky. Thanks Kim!
I carry my stuff in a laptop bag by Reiter8. It's water resistant, which is important because I lose every umbrella I touch. Not so lucky there.
And what software?
Same thing with Skitch. Fantastic app that changed the way I work with other people.
My files gets backed up to S3 using Arq, my computer screen doesn't dim unless I want it to thanks to Caffeine, and I take pictures of myself all the time with Photo Booth. Not because I'm vain (though there is that), but because I proudly subscribe to Stunners of the Month and like to photograph each new pair I receive.
Oh, and I play a lot of Carcassonne.
What would be your dream setup?
Thought-controlled software and a wireless internet connection in my brain, integrated right into my field of vision. I think I would give up my mouse for that.